• Age 45-81 years
• Willing to complete a screening colonoscopy
• Has not undergone colonoscopy within last 7 years
• Have not had a positive result on another colorectal cancer screening method within the last six months, or:
  • 12 months for fecal occult blood test (FOBT) or fecal immunochemical test (FIT)
  • 36 months for FIT-DNA test
• No history of colorectal cancer or positive family history of colorectal cancer
• Do not have a colonoscopy scheduled to investigate gastrointestinal symptoms

• Health Insurance Coverage is required.
• Study participants will have 2 office visits over 3 years
• Study participants may receive compensation of up to $450 for time and travel if deemed eligible to participate which will be determined during the first visit.
• The study would provide participants with the screening, study related office visits, and lab tests at no cost
• Patients will be directed to their own doctor for normal care/non-study related health concerns.
• The enrolled patients will receive a Shield test in the initial year of enrollment. Additionally, at the time of enrollment, individuals will consent to switch screening tests and undergo a screening colonoscopy at the second colorectal cancer testing interval along with a single blood draw consisting of up to 40 mL

• At least 18 years of age
• Presence of diabetic peripheral neuropathy, symmetrical in nature in lower extremities for ≥ 6 months
• Diagnosed with type 1 or type 2 diabetes and A1c ≤ 11%
• Willing to discontinue all medications taken for chronic pain, except acetaminophen, for the duration of the study
• Have not had a procedure in the last 6 months to produce permanent sensory loss in the target area
• Do not have fibromyalgia
• Do not have an intolerance to acetaminophen or paracetamol

• There will be approximately 8 office visits over a period of approximately 10 weeks.
• Patients may be compensated for their time and travel if deemed eligible to participate.
• Patients will receive study-related care, office visits, physical exams, and lab tests at no cost.
• Patients will be directed to their own doctor for normal care/non-study related health concerns.

• At least 18 years of age
• Must be able to read and understand English
• Must be willing to allow venous samples to be obtained to test HbA1c, Fasting Plasma Glucose (FPG) and 75-gram oral glucose tolerance test (OGTT)
• Not diagnosed with type 1 diabetes, type 2 diabetes or gestational diabetes
• Not currently practicing a low-carbohydrate or ketogenic diet
• Does not have a known allergy to medical grade adhesive, isopropyl alcohol and/or ethyl alcohol used to disinfect skin
• Not currently on any form of treatment indicated for the treatment of diabetes or weight loss, including metformin and GLP-1 or combination GLP/GIP agonists (e.g. Ozempic, Rybelsus, Trulicity, Victoza, Byetta, Bydureon BCise, Wegovy, Mounjaro, Zepbound, Saxenda).

• There will be about 3 study visits over about 3 months.
• Patients may be compensated up to $310 if all visits are completed.
• Patients will receive study related care, office visits, physical exams, and lab tests at no cost.
• Patients will be directed to their own doctor for normal care/non-study related health concerns.

• At least 18 years of age
• Meet one of the following:
  • BMI ≥ 30 OR
  • BMI ≥ 27 with a history of one of the following:
    • Hypertension (high blood pressure)
    • Dyslipidemia (high or low cholesterol)
    • Obstructive sleep apnea
    • Cardiovascular disease
• Stable body weight for the last 90 days
• At least one unsuccessful dietary effort to reduce body weight
• Do not have type 1 diabetes, type 2 diabetes or any other type of diabetes or history of ketoacidosis
• Have not had any of the following in the last 90 days: myocardial infarction (MI), stroke, coronary artery revascularization, unstable angina, or hospitalization due to congestive heart failure
• Are not receiving metformin or any other glucose-lowering medication, regardless of the indication for use, in the last 90 days
• Have not taken in the last 90 days prescribed or over-the-counter medications or alternative remedies, including herbal or nutritional supplements, intended to promote body weight reduction

• There will be up to 24 office visits over a period of up to 3.5 years
• Patients may be compensated for their time and travel if deemed eligible to participate.
• Patients will receive study related care, office visits, physical exams, and lab tests at no cost.
• Patients will be directed to their own doctor for normal care/non-study related health concerns.

• Male or female over the age of 18
• Diagnosis of Parkinson’s disease
• Has Internet access to provide data online

For more information please visit:  www.foxinsight.org/clinic

• Surveys on health-related topics to be completed every 3 months for 5 years
• Optional, one-time surveys and sub-studies including genetic testing and counseling at no cost
• Appointment reminders and physician reports online for patients