Current Clinical Trials

Studies listed below are currently open to accept new study patients. If you believe you might meet the baseline criteria, or would simply like more information, please contact us.

Condition Study Name Criteria Additonal Information
Breast Cancer Breast Cancer Screening Study
  • Are between the ages of 40-74 years old
  • Have never been diagnosed with breast cancer or DCIS
  • Have no history of mastectomy in both breasts
  • Get your mammograms in California

Introductory video: https://youtu.be/T7ws9Ewvvis

  • Participation is easy and can be done from home. There are no study visits, doctor’s appointments, or additional lab tests. You don’t need to change health care providers to be part of this study.
  • Study participation may include genetic testing, consultations with a Breast Health Specialist, and risk assessment. There will be no cost to you for these services.
  • The main study lasts for five years and involves answering a health history questionnaire and completing follow-up questionnaires every year.
  • If selected for the personalized screening group, you will be asked to provide a saliva sample, by mail, to look for genetic risk factors for breast cancer.
Cardiovascular Risk CV Risk in Overweight or Obese Patients
  • ≥45 years of age
  • Body mass index (BMI) ≥ 27 kg/m2
  • Have established CV disease as evidenced by at least one of the following:
  •   prior myocardial infarction
  •   prior stroke (ischemic or hemorrhagic stroke)
  • Does NOT have diabetes.
  • Patients will be directed to PCP for normal care/non-study related health concerns
  • Patients may receive reimbursement for participating
  • The study involves about 17 visits and phone contacts every 6 months over approximately 5 years 
Depression Voice Assessment for Depression and Anxiety
  • Between 18-70 years of age
  • Access to mobile telephone
  • Medical records at DOHC
  • Diagnosis of depression 
  • Does NOT have a history of:
    • Parkinson’s Disease
    • Stroke or head trauma within last 12 months
    • Schizophrenia or psychosis
  • Patients will be directed to PCP for normal care/non-study related health concerns
  • Patients may receive reimbursement for participating
  • The study involves 1 office visit and 6 phone contacts over 5 weeks
Diabetes Type 2 Diabetes with CV Disease
  • Age > 18 years old
  • HbA1c  > 7.5% and < 10.5%
  • Taking 1- 3 of the following OAD’s: metformin, sulfonylurea and SGLT-2i
  • Body mass index (BMI) ≥ 25 kg/m2
  • CV disease with at least one of the following:
  1. prior myocardial infarction
  2. >50% stenosis major coronary artery
  3. Stable, treated angina pectoris
  4. Prior coronary revascularization
  5. Asymptomatic cardiac ischemia
  6. Coronary calcium score >300
  7. Hx of ischemic stroke w/atherosclerotic origin                                                             OR

Peripheral Arterial Disease w/atherosclerotic origin OR

Age > 50 years and ONE of the following: a) CHF class II or III or b) Hx of TIA w/atherosclerotic origin

  • Patients will be directed to PCP for normal care/non-study related health concerns
  • Patients will receive study medication at no cost during the course of the study
  • Patients will receive lab tests, physical exams, and study related care at no cost
  • Patients may receive reimbursement for participating
  • The study involves about 27 office visits and 4 phone calls over approximately 2 years 
Diabetes Type 2 Diabetes (T2D) with Cardiovascular Disease (CVD)
  • ≥50 years of age
  • HbA1c 6.5% and 10.0%
  • At least one of the below conditions (a-d):
    • a) Coronary heart disease defined as at least one of the following:
      • i. Prior myocardial infarction
      • ii. Prior coronary revascularisation procedure
      • iii. ≥50% stenosis in coronary artery documented by cardiac catheterisation or CT coronary angiography
      • iv. Coronary heart disease with ischaemia documented by stress test with any imaging modality 
    • b) Cerebrovascular disease defined as at least one of the following:
      • i. Prior stroke
      • ii. Prior carotid artery revascularisation procedure
      • iii. ≥50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound
    • c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following:
      • i. Intermittent claudication with an Ankle-brachial index (ABI) < 0.85 at rest
      • ii. Intermittent claudication with a ≥50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound
      • iii. Prior peripheral artery (excluding carotid) revascularization procedure
      • iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis)
    • d) Chronic kidney disease defined as:
      • i. eGFR < 60 mL/min/1.73 m2 b
  • Patients will be directed to PCP for normal care/non-study related health concerns
  • Patients will receive study medication at no cost during the course of the study
  • Patients will receive lab tests, physical exams, and study related care at no cost
  • Patients may receive reimbursement for participating
  • The study involves about 27 visits over approximately 3-5 years 
Diabetes Type 2 Diabetes (T2D) and Chronic Kidney Disease (CKD)
  • ≥ 18 years of age
  • T2D
  • HbA1c ≤ 10%
  • Moderate CKD (eGFR> 25 and < 75 mL/min/1.73 m2)
  • Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), unless such treatment is contraindicated or not tolerated.
  • Patients will be directed to PCP for normal care/non-study related health concerns
  • Patients will receive study medication at no cost during the course of the study
  • Patients will receive lab tests, physical exams, and study related care at no cost
  • Patients may receive reimbursement for participating
  • The study involves about 18 visits and 11 phone contacts over approximately 5 years 
Low Testosterone Low Testosterone with Cardiovascular Disease
  • 45 to 80 years of age (inclusive)
  • Diagnosis of clinical hypogonadism AND presence of at least one of the following: decreased sexual desire/libido, decreased spontaneous erections, decreased energy/fatigue, low/depressed mood, loss of body (axillary and pubic) hair, hot flashes.
  • Have pre-existing CV disease OR at least 3 of the following risk factors: hypertension, dyslipidemia, current smoker, stage 3 chronic kidney disease, diabetes, elevated hsCRP, ≥ 65 years of age.
  • Does NOT have any major surgeries scheduled or planned.
  • Patients may receive reimbursement for participating
  • The study involves about 17 visits and phone contacts every 6 months over approximately 5 years 
Parkinson's Disease Parkinson's Disease (PD) - Online Study
  • Male or female over the age of 18
  • Diagnosis of Parkinson’s disease
  • Has Internet access to provide data online

For more information please visit:  www.foxinsight.org/clinic

  • Surveys on health-related topics to be completed every 3 months for 5 years
  • Optional, one-time surveys and sub-studies including genetic testing and counseling at no cost
  • Appointment reminders and physician reports online for patients